在内皮2插入了一个单个的loxP位点,然后在内皮3插入了loxP标记的诺卡因和胸腺嘧啶激酶选择性载体。在将选择性载体通过暂时的Cre表达从胚胎干细胞中去除后,生产了嵌合小鼠,最终等位基因中,exon 2被loxP位点 flank。Cre介导的重组在生殖细胞中删除了exon 2。(来源:J:63039, J:284174)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
插入,基因内删除
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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