在exon 1的上游插入了loxP位点,紧接着是ATG起始点,然后在exon 1的下游插入了带有FRT标记的neo cassette和另一个loxP位点。通过Flp酶介导的重组移除了neo cassette,而cre介导的重组则去除了exon 1。(来源:J:199632)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count