包含EGFP报告基因、polyadenylation信号和F3介导的 puromycin抗性基因座的靶向载体被插入到exon 2,导致exon 2部分缺失,同时exons 3和4也被删除。通过Flp介导的重组,去除了含FRT标记的puro cassette。(来源:J:236888)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count