第9外显子被替换成一个带有floxed Neo抗性标记的 cassette,同时对第9外显子进行了一处核苷酸替换,从GCT变为ATG,导致第68位的甲硫氨酸被缬氨酸取代。这种突变模拟了与精神类疾病关联的人类多态性。随后,通过Cre介导的重组移除了选择性标记(cassette)。(来源:J:284662)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJcl
Targeted
Insertion, Nucleotide substitutions
--
1
2
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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