H2-Ab1^g7-em2Ygch

The zinc finger nuclease induced mutation targets residue 57 of the gene, resulting in a serine to aspartic acid mutation (S57D). The mutation at position 57 (S57D) in the MHC class II A chain disrupts the expression of the diabetes susceptible MHC class II I-Ag7 molecule uniquely expressed in NOD mice. (J:284226)