鼠的人工染色体(MAC)技术克隆了HSA21染色体的34MB长臂(HSA21q)。MAC转基因包含了由CAG启动子驱动的EGFP报告基因,周围有HS4绝缘子,一个PGK-诺卡因插件,3'的loxP-HPRT位点,PGK-puromycin插件,以及端粒。线1已经产生。(来源:J:297246)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Not Applicable
插入
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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