在两个位置引入了A到T的核苷酸替换,导致第114位的酪氨酸变为苯丙氨酸(Y114F),第207位的酪氨酸也变为苯丙氨酸(Y207F)。随后插入了一个FRT引导的诺卡因抗性基因座,位于这两处变异之后。这俩突变阻碍了铁在转铁蛋白N环上的结合。(来源:J:282105)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
Insertion, Nucleotide substitutions
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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