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CRISPR/cas9导向的基因编辑通过在Gt(ROSA)26Sor基因座插入一个含loxP停聚子的CAG-H2B-miRFP703(核定位)载体来实现，这个载体带有克隆的STOP cassette。在体外通过Cre酶反应移除了这个停聚子。miRFP703源自miRFP670，miRFP670则来源于细菌的植物光受体 RpBphP1，来自罗德尼萨普汉萨克罗宾斯（Rhodopseudomonas palustris）。miRFP703的变异包括D16S/L17H/C20S/R22H/P43H/I47V/D106C/P127S/A155V/E179L/R184C/D201T/I202V/R208Q/E211V/S222T/I253C/Y257F/N260D/V268A/A282V/H292R/E300K/L301R/A305R/S20C/T201L/C253I。（来源：J:266345）
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
