在exon 4上游插入了loxP位点。下游插入了一个带有splice接受器、IRESEncoder和GFP报告基因的敲除 cassette。通过Flp介导的重组,移除了之前位于报告 cassette内的FRT标记的诺卡因抗性基因 cassette。免疫组化证实了在ARC神经元中转录表达的减少。(来源:J:281818, J:277600)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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