CRISPR对exon 6的58bp缺失区域进行了靶向,该区域包含Nudixmotif的关键催化残基。 Western blot结果显示肝脏和肾脏中没有蛋白表达(来源:J:282288)
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CRISPR-targeting of exon 6 deleted 58 bp, containing the critical catalytic residues of the Nudix motif. Western blot analysis confirmed the absence of protein expression in the liver and kidney. (J:282288)