靶向载体被设计成在基因的第五外显子下游插入一个FRT引导的诺卡因抗性(neo)元件。第六外显子被改造以包含人类中Sting最常见的等位变异(R231H),类似于R232H。通过Flp介导的重组,FRT引导的neo元件被移除。(来源:J:331747)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
核苷酸替换
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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