这个构建包含pCAGG启动子、一段由loxP位点标记的β-Geo终止子、人PTPN1带有3X-FLAG标签、插入的内切位点序列(IRES)以及EGFP,它被插入到了特定的基因位点。只有在通过Cre介导的重组移除终止子后,插入的鼠基因和报告基因才会表达(来源:J:231906)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(129X1/SvJ x 129S1/Sv)F1-Kitl+
Targeted
插入
--
--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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