在exon 1上游插入了loxP位点,通过同源重组,又插入了由FRT引导的pgk-neo cassette和一个loxP位点在exon 1下游。随后,Flp介导的重组去除了pgk-neo cassette。(来源:J:279065, J:280829)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count