CRISPR/Cas9技术通过oligo1(序列TAGGCCTTGGAGCCCC-CACGGT)和oligo2(序列AAAC ACCGTGGGGGCTCCAAGG)产生了一个22bp的缺失,发生在exon 2(第33-3位置)。 Western blot结果显示心肌中没有蛋白质表达(来源J:280190)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Endonuclease-mediated
基因内删除
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1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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