在exon 1b的上游插入了一个带有5' loxP位点的FRT引导的诺卡因抗性 cassette,随后在exon 1b的下游插入了另一个loxP位点。通过Flp酶介导的重组移除了选择 cassette,而Cre介导的重组则剔除了exon 1b。这些小鼠无法表达脑特异性的renin-b,但能产生肾特异性的renin-a。(来源:J:278974)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
插入,基因内删除
--
1
3
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
Show/Hide columns
Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
微信
信息比对
科研助手
使用教程
回到顶部