在第2264位由T变为A的核苷酸变异,导致第755位的valine替换为glutamate,发生在exon 17。同时,exon 17内插入了由loxP序列 flank的抗氨苄青霉素耐药基因。在ES细胞中,通过Cre介导的重组去除了选择性载体。(来源:J:257856)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(129S6/SvEvTac x C57BL/6NCrl)F1
Targeted
Insertion, Single point
--
1
4
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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