在第2264位由T变为A的核苷酸变异,导致第755位的valine替换为glutamate,发生在exon 17。同时,exon 17内插入了由loxP序列 flank的抗氨苄青霉素耐药基因。在ES细胞中,通过Cre介导的重组去除了选择性载体。(来源:J:257856)
Basic Information
(129S6/SvEvTac x C57BL/6NCrl)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count