这个转基因插入包含以下组件:人类间歇性视黄醇结合蛋白3的启动子、带有两种突变(p.R172W和p.P341Q)的鼠Prph基因克隆,以及SV40的poly(A)尾巴序列。Arg172Trp的突变模拟了某些人类因视网膜退化而发现的突变。Pro341Gln的改变是为了能通过单克隆抗体3B6识别肽。来源:(J:92815)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
CD-1
--
插入
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1
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6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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