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中文
通过CRISPR/Cas9技术，使用sgRNA5'-CTCTTTGCAGGTCCATCGGC-3'和一个121bp的单链脱氧核糖核酸模板，产生了一个c.1580A>G的点突变，将His527的histidine密码子替换为Arg的arginine密码子（p.His527Arg）。这个突变模拟了部分人类家族性Wolff-Parkinson-White（WPW）综合症患者中发现的p.His530Arg变异（来源：J:278059）。
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
