在这个微小RNA簇中,Mir29a和Mir29b1通过同源重组被一个由EM7/PGK启动子驱动的puromycin/thymidine kinase融合基因替换。插入的选择性载体被loxP和F3/FRT序列 flank。随后,通过Cre介导的重组,替换载体被剔除。(来源:J:174268, J:267719)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
Insertion, Intergenic deletion
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2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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