基因的编码外显子3在5'端由loxP位点起始,接着是位于终止密码子下游的第二个loxP插入,这样通过Cre介导的重组会引发整个编码区域和剪接位点的缺失。通过Flp介导的重组,在生殖细胞中移除了含neo抗性基因的frt标记片段。(来源:J:278651)
Basic Information
(C57BL/6NTac x 129S6/SvEvTac)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count