基因的编码外显子3在5'端由loxP位点起始,接着是位于终止密码子下游的第二个loxP插入,这样通过Cre介导的重组会引发整个编码区域和剪接位点的缺失。通过Flp介导的重组,在生殖细胞中移除了含neo抗性基因的frt标记片段。(来源:J:278651)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NTac x 129S6/SvEvTac)F1
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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