CRISPR/Cas9技术通过sgRNA5'-TAGGGCTATGTCTGAGCCAG-3'和捐赠寡核苷酸,产生了T>C的突变,将 cysteine (C14) 的密码子替换为 arginine (CGT),产生了p.C14R。这种突变在一些Ly5.1(B6.SJL-Ptprca Pepcb/BoyJ)小鼠群体中自发出现,参考文献为J:278854。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6
Endonuclease-mediated
单点
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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