使用小鼠胚胎干细胞中传统的同源重组方法,将tetracycline控制的转录激活器(tTA)靶向插入内源性eukaryotic翻译延长因子1α1(EEF1a1)基因座的第1内含子。tTA前面有一个剪接接受位点和一个带有三个polyA信号的无启动子的neo序列(即无启动子的neo,带有三个polyA标记)。(来源:J:292860)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/SvImJ or C57BL/6J
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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