通过Cre介导的Nintm1c(EUCOMM)Hmgu等位基因的去除,导致了exon 2的缺失。免疫印迹和免疫染色的检测确认了胚胎纤维细胞和皮肤切片中均无蛋白表达。欲了解针对此类IKMC等位基因的其他靶向策略,请访问http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml(来源:J:277726)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count