在exon 14的上游插入了loxP位点,通过同源重组在exon 14下游插入了带有FRT标记的neo cassette和另一个loxP位点。通过重组酶介导的重组,exon 14和neo cassette被移除。实时PCR结果显示成年纯合突变小鼠睾丸、肺、肝脏和肾脏中mRNA表达显著减少。(来源:J:273740, J:272184)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count