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中文
CRISPR/Cas9技术通过针对exon 2使用四种gRNA，对五个高度同源基因的复制品进行干扰，总共删除了90kb的序列（103731876-103822024），导致Serpina1b和1d基因的去除。转录组分析确认了这些基因的无表达状态。 Western blot实验证实了血清中没有检测到alpha1-抗胰蛋白酶蛋白。(来源：J:259615)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
