Tmem43^em1Chen

Using CRISPR/Cas9 with a donor oligonucleotide, a double substitution was introduced (CC>TA) to change serine codon 358 (TCC) to a leucine codon (TTA) (p.Ser358Leu). This mutation mimics the mutation seen in human arrhythmogenic right ventricular cardiomyopathy (ARVC) patients. (J:267849)