TALEN基因编辑技术被用来产生一个75bp的DNA缺失,导致exon3发生异常剪接,进而产生一个由159个氨基酸组成的截短蛋白。在来自突变小鼠的线粒体中未检测到这种蛋白。(来源:J:242351)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
FVB/N
Endonuclease-mediated
基因内删除
--
1
3
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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