一个靶向载体来自KOMP合作组织(项目CSD48807,克隆HTGRS01006_A_B09),并转染到了V6.5的ES细胞中。在内皮1中插入了frt-lacZ-loxP-neomycin选择 cassette-frt-loxp构建,同时在内皮2中插入了一个loxP位点。通过Cre介导的重组在生殖细胞系中导致了exon 2的缺失。(来源:J:264769)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129S4/SvJae)F1
Targeted
插入,基因内删除
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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