使用含有Frt-flanked Neo耐药基因(Neo)、胸苷激酶和编码IRES-eGFP-iCre融合蛋白片段的靶向构建,在ES细胞中通过同源重组,将报告基因插入Klrg1基因的终止密码子后。随后,将这些转基因小鼠与FLPo小鼠杂交,以剔除Neo基因(J:272661)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
--
1
--
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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