在位置2053的保守丝氨酸被替换为天冬氨酸,并插入了一个FRT引导的neo cassette,通过同源重组在上游内含子中。通过Flp介导的重组移除了neo cassette。这种突变产生了一个磷酸类似物的替换蛋白。(来源:J:220823)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
核苷酸替换
--
1
2
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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