原生位点的exon 2被一段由exons 2-16,前后带有loxP位点的cDNA替换,接着是一个内源性核糖体进入信号(IRES),以便从插入的细菌lacZ基因中表达β-半乳糖苷酶。通过Cre介导的生殖细胞重组,去除了loxP标记序列,只表达细菌lacZ基因。(来源:J:241326)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd
Targeted
插入,基因内删除
--
1
1
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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