在基因1的内含子中插入了一个由反向排列的FRT/F3和lox511/loxP这种异型的FRT/FRT和Cre酶识别序列簇构成的基因捕获载体。FLP重组酶的表达将基因捕获从其编码(致病性)方向翻转为反义,从而驱动基因的表达(敲除等位基因)。当Cre表达时,会通过重新定向基因捕获回其编码方向,产生一个恢复突变的敲除等位基因。(来源:J:275367)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
插入
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1
3
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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