在exon 3的上游插入了含弗里特-弗林基因(Frt-flanked neomycin selection cassette)的元件和一个loxP位点,接着在exon 3的5'端也插入了另一个loxP位点。通过FLP介导的重组,弗里特-弗林基因的筛选元件被移除。(来源:J:249241)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count