Scn1a^em1Dsf

CRISPR/Cas9 genome editing is used to introduce an A>T point mutation at nucleotide 1837 (converting arginine (R) 613 to a STOP (X) codon) and a silent C>T mutation at position 1833 into exon 12. Mutations in Scn1a are associated with Dravet Syndrome. (J:101977)