Rr102^tm1.2Ics

An FRT site flanked neomycin resistance cassette and a loxP site flanked chicken transcriptional enhancer element A that contains specific mutations in the Egr2 binding sites that prevent binding of wild-type Egr2 and instead allow binding of a mutant Egr2 protein, and an F3-flanked mouse element A replaced the wild-type Egr2 autoregulatory element A. Flp-mediated recombination removed the F3 flanked mouse element A and the neo cassette and cre-mediated recombination removed the floxed chicken element A. (J:277269)