Del(18Pcdha-Pcdhb)2Tyag

This allele follows the meiotic cre-mediated recombination between the Pcdhatm13Tyag and Pcdhbtm2Tyag alleles. The Pcdhatm13Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette followed by a myc-tagged Venus fluorescent protein gene cassette inserted into the 5' end of the first exon, alpha1, of the first gene in the cluster, Pcdha1. The Pcdhbtm2Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette inserted downstream of the last gene, Pcdhb22, in the cluster. Recombination between the two results in the complete deletion of the Pcdha and Pcdhb clusters plus the Venus gene and the two neo cassettes. (J:244163)