靶向载体构建是为了插入Frt引导的neo选择子和IRE-Sce序列,以及在Defa4基因的第二外显子。生成的实验鼠与FloO剔除者杂交,以去除neo选择子。Sce的表达仅限于小肠中Paneth细胞。(来源:J:273741)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Not Specified
Targeted
插入
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4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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