An IRES-iCRE-loxP-Cre-NeoR-loxP cassette was introduced in the 3' untranslated region of the Clec4f gene, downstream of the stop codon by homologous recombination. Germline transmission led to the self-excision of the loxP-Cre-NeoR-loxP cassette in male germinal cells. (J:274437)