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中文
小鼠胸腺细胞抗原驱动元件(Thy1)主要在大脑皮层的锥体细胞中，从出生后开始，驱动表达人类APP(APP-751)携带瑞典双突变K670N和M671L，以及印第安纳突变V717F的cDNA。通过Southern blot检测，估计转基因拷贝数大约为20。 Western blot结果显示，该转基因在海马和大脑皮层中均有过量表达。这些小鼠在大脑皮层和海马中，平均来说，APP42的表达是APP40的2倍。(来源：J:251735)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
