通过修改RP23-39F11小鼠BAC克隆,插入了核定位信号(Cre-pA) cassette和FRT-Amp-FRT序列到Slc6a4基因的起始翻译位点,构建了Tg构造。在获得的BAC构建中,通过细菌中的flp/FRT重组去除了Amp序列。Tg纯合品系小鼠通过将线性化构建注入C57BL/6受精卵中产生。总共产生了至少六条品系,其中两条(208和810)显示出相似的表达模式。(来源:J:216132)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6
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插入
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3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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