Igh 3'调控区(3'RR)调控B细胞的类别转换重排(CSR)和体细胞高频突变(SHM)。小鼠的3'RR包含四个增强子元件,包括hs1,2(称为Rr153),它们被倒置重复间隔序列(IRIS)包围,中心是一个25kb的回文结构,由两个反式增强子副本(hs3a, Rr154和hs3b, Rr155)界定。增强子hs4(称为Rr156)位于回文结构下游。这个等位基因完全去除了左侧的IRIS,但保留了所有四个核心增强子元件。(来源:J:234741)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
基因间区删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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