CRISPR对携带有Thratm1Ffla基因,5'末端有floxed neo cassette插入,这个cDNA编码了L400R氨基酸替换的开放阅读框,以及3'端带有IRES-Tau-lacZ序列的胚胎,导致了从位置393开始的框架移位和在401位获得终止密码子的变异。(来源:J:268664)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Endonuclease-mediated
未定义
--
1
2
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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