这项研究通过将100ng/ul的FLP mRNA( Miltenyi BIotec Inc.,产品号130-106-769)微注射到IVF衍生的囊胚细胞质中,去除了Ptprstm1a(KOMP)Mbp这一特定等位基因(MGI:4840831)中的FLP剪接区。这导致了neo选择座和lacZ报告基因的消除,保留了关键的外显子。更多细节可在http://www.mousephenotype.org/data/genes/MGI:97815查阅(J:200814)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6N-Atm1Brd
Targeted
插入
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1
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5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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