Crybg1tm1a(KOMP)Wtsi这一突变(MGI:5008764)是通过FLP酶切去除了neo选择子和lacZ标记,保留了关键外显子。欲了解针对此类IKMC突变以及其他类似基因的靶向策略详情,可访问http://www.knockoutmouse.org/about/targeting-strategies(来源:J:200814)。
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count