这个来自TCPR0556项目的等位基因是在phenogenomics中心通过向细胞注射Cas9 mRNA和四种引导RNA,这些RNA带有AAGAAATAAGTTGCCCTCAT和ATACCTGATTGGATCAAGAT的 spacer序列,目标是染色体14的5'端,以及CCAGTTGGTAGTATCCTTAG和CTTGCTCCCACTCTGAAGTG针对的是ENSMUSE00000558006、ENSMUSE00000558005和ENSMUSE00000558003这三个基因的3'端。这导致了14号染色体61,179,235到61,184,968的5,734bp缺失(GRCm38,J:200814)。

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
4
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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