这个来自TCPR0501项目的等位基因是在phenogenomics中心通过向细胞注射Cas9 mRNA和四种引导RNA,这些RNA带有AGGTGCTTAGATTCTTGATT和CATTTAGTCCCATCCCAACC的 spacer序列,目标是染色体7的5'端,以及TTAGGCACCGAAGGTTCAGG和GAGTCTTCCGCCTGAACCTT针对3'端的ENSMUSE00000388025(也就是基因2的exon 2),导致了740bp的染色体7缺失,位置从48552089到48552828(GRCm38)。(J:200814)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NCrl
Endonuclease-mediated
基因内删除
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1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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