将终止密码子TAATAA插入第2外显子,导致该外显子的翻译被终止,从而移除了Ig1区域。接着在第3外显子上游和下游分别插入了loxP和FRT-neo-FRT-loxP序列。 Western blot结果显示,纯合小鼠大脑中仅表达NP55亚型,而非NP66亚型。(来源:J:276256)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Specified
Targeted
插入
--
1
--
4

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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