CRISPR通过sgRNAS针对TGGCAGGATTAGCAGTTCAG和GGACTAGAGACTCTTCCACT设计,将一个兔β-球蛋白的转录终止子序列插入到了Angelman综合症 imprinting中心(AS-IC)的上游U1外显子上游28.6kb处,以及Snrpn启动子上游14.3kb处。使用了三个不同的供体。(来源:J:270068)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count