CRISPR通过sgRNAS针对TGGCAGGATTAGCAGTTCAG和GGACTAGAGACTCTTCCACT设计,将一个兔β-球蛋白的转录终止子序列插入到了Angelman综合症 imprinting中心(AS-IC)的上游U1外显子上游28.6kb处,以及Snrpn启动子上游14.3kb处。使用了三个不同的供体。(来源:J:270068)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
C57BL/6J
Endonuclease-mediated
插入,基因内删除
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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