Abca3^tm1.1Smgt

Glutamic acid codon 292 (GAG) in exon 9 was changed to valine (p.E292V). Flp-mediated recombination removed the FRT site flanked neomycin resistance gene cassette inserted into intron 8. The mutation represents the same human mutation associated with neonatal respiratory distress syndrom, childhood interstitial lung disease and diffuse parenchymal lung disease (DPLD) in adults. (J:274491)