对于Tg(Myh6-cat)7Rbns和Tg(Myh6-cat)27Rbns这两个基因的转基因构建,我们对位于-327..-314(相对于转录起始点)的Mef2a结合位点进行了改造,通过定点突变,将野生型的TTAAAAATAACTGA替换成了TGACCACTCCATGC。(来源:J:4164)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count